Journal article
A tRial Evaluating Mid Cut-Off Value Membrane Clearance of Albumin and Light Chains in HemoDialysis Patients: A Safety Device Study
Rathika Krishnasamy, Carmel M Hawley, Meg J Jardine, Matthew A Roberts, Yeoungjee Cho, Muhgeot Wong, Anne Heath, Craig L Nelson, Shaundeep Sen, Peter F Mount, Elaine M Pascoe, Liza A Vergara, Peta-Anne Paul-Brent, Nigel D Toussaint, David W Johnson, Colin A Hutchison
Blood Purification | KARGER | Published : 2020
DOI: 10.1159/000505567
Abstract
BACKGROUND: A new class of dialysis membrane, the mid cut-off (MCO) dialyzer, has been developed to improve the clearance of uremic toxins in hemodialysis (HD). The a tRial Evaluating Mid cut-Off Value membrane clearance of Albumin and Light chains in HemoDialysis patients (REMOVAL-HD) study aimed to determine if regular use of MCO dialyzer was safe and specifically did not result in a significant loss of albumin. METHODS: This investigator initiated, crossover, longitudinal, device study was conducted across 9 centers in Australia and New Zealand (n = 89). Participants had a 4-week wash-in with high-flux HD, followed by 24-week intervention with MCO HD and a subsequent 4-week wash-out with ..
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Funding Acknowledgements
Baxter Investigator Initiated Research Grant and Kidney Health Australia via the AKTN. This is an investigator-initiated study and Baxter had no role in study design, conduct, data collection, analysis and preparation of this manuscript.