Journal article
A trial evaluating mid cut-off value membrane clearance of albumin and light chains in hemodialysis patients: A safety device study
R Krishnasamy, CM Hawley, MJ Jardine, MA Roberts, Y Cho, M Wong, A Heath, CL Nelson, S Sen, PF Mount, EM Pascoe, LA Vergara, PA Paul-Brent, ND Toussaint, DW Johnson, CA Hutchison
Blood Purification | KARGER | Published : 2020
DOI: 10.1159/000505567
Abstract
Background: A new class of dialysis membrane, the mid cut-off (MCO) dialyzer, has been developed to improve the clearance of uremic toxins in hemodialysis (HD). The a tRial Evaluating Mid cut-Off Value membrane clearance of Albumin and Light chains in HemoDialysis patients (REMOVAL-HD) study aimed to determine if regular use of MCO dialyzer was safe and specifically did not result in a significant loss of albumin. Methods: This investigator initiated, crossover, longitudinal, device study was conducted across 9 centers in Australia and New Zealand (n = 89). Participants had a 4-week wash-in with high-flux HD, followed by 24-week intervention with MCO HD and a subsequent 4-week wash-out with ..
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Funding Acknowledgements
Baxter Investigator Initiated Research Grant and Kidney Health Australia via the AKTN. This is an investigator-initiated study and Baxter had no role in study design, conduct, data collection, analysis and preparation of this manuscript.