The murine CD94/NKG2 ligand, Qa-1(b), is a high-affinity, functional ligand for the CD8?? homodimer
Katharine Jennifer Goodall, Angela Nguyen, Craig McKenzie, Sidonia Barbara Guiomar Eckle, Lucy Catherine Sullivan, Daniel Mark Andrews
Journal of Biological Chemistry | AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC | Published : 2020
The immune co-receptor CD8 molecule (CD8) has two subunits, CD8α and CD8β, which can assemble into homo or heterodimers. Nonclassical (class-Ib) major histocompatibility complex (MHC) molecules (MHC-Ibs) have recently been identified as ligands for the CD8αα homodimer. This was demonstrated by the observation that histocompatibility 2, Q region locus 10 (H2-Q10) is a high-affinity ligand for CD8αα which also binds the MHC-Ib molecule H2-TL. This suggests that MHC-Ib proteins may be an extended source of CD8αα ligands. Expression of H2-T3/TL and H2-Q10 is restricted to the small intestine and liver, respectively, yet CD8αα-containing lymphocytes are present more broadly. Therefore, here we so..View full abstract
Awarded by National Health and Medical Research Council (NHMRC)
This work was supported by National Health and Medical Research Council (NHMRC) Grant APP1141950 (to L. C. S.).