Journal article

Sex differences in infant blood metabolite profile in association with weight and adiposity measures

Susan Ellul, Anne-Louise Ponsonby, John B Carlin, Fiona Collier, Toby Mansell, Peter Vuillermin, David Burgner, Richard Saffery

Pediatric Research | NATURE PUBLISHING GROUP | Published : 2020


BACKGROUND: Nuclear magnetic resonance (NMR) metabolic profiling quantifies a large number of metabolites. From adolescence, specific metabolites are influenced by age, sex and body mass index; data on early-life metabolic profiles are limited. We investigated associations between sex, birth weight, weight and adiposity with NMR metabolic profile at age 12 months. METHODS: The plasma NMR metabolic profile was quantified in infants (n = 485) from the Barwon Infant Study. Associations between 74 metabolites and sex, birth weight z-score and 12-month measures (weight z-score, skinfold thickness, weight-for-length z-score) were examined using linear regression models. RESULTS: Several cholestero..

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