Journal article

The association of antihypertensive use and depressive symptoms in a large older population with hypertension living in Australia and the United States: a cross-sectional study

Bruno Agustini, Mohammadreza Mohebbi, Robyn L Woods, John J McNeil, Mark R Nelson, Raj C Shah, Anne M Murray, Michael E Ernst, Christopher M Reid, Andrew Tonkin, Jessica E Lockery, Michael Berk

Journal of Human Hypertension | SPRINGERNATURE | Published : 2020

Abstract

Cardiovascular drugs impact many pathways involved in depression pathophysiology and treatment. However, their distinct impact on mood is underrecognized and the literature is conflicting. Therefore, using a very large and well-characterised sample of older adults with hypertension, we aimed to investigate the prevalence of depressive symptoms in users of different antihypertensive classes. We analysed baseline data from 14,195 older individuals with hypertension enroled in a large clinical trial. Median age was 75 years. The association of antihypertensive use by class and depression prevalence, as measured by a validated depression scale, was determined using logistic regression models. Mu..

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Grants

Awarded by National Institute on Aging


Awarded by National Cancer Institute at the National Institutes of Health


Awarded by National Health and Medical Research Council of Australia


Awarded by NHMRC Senior Principal Research Fellowship


Awarded by NHMRC Senior Research Fellowship


Funding Acknowledgements

The study is supported by the National Institute on Aging and the National Cancer Institute at the National Institutes of Health (grant number U01AG029824); the National Health and Medical Research Council of Australia (grant numbers 334047 and 1127060); Monash University (Australia); the Victorian Cancer Agency (Australia). MB is supported by a NHMRC Senior Principal Research Fellowship (APP1059660 and APP1156072) and CMR is supported by a NHMRC Senior Research Fellowship (APP1045862).