Journal article

Effects of aging on the motor, cognitive and affective behaviors, neuroimmune responses and hippocampal gene expression

Gaurav Singhal, Julie Morgan, Magdalene C Jawahar, Frances Corrigan, Emily J Jaehne, Catherine Toben, James Breen, Stephen M Pederson, Jim Manavis, Anthony J Hannan, Bernhard T Baune

Behavioural Brain Research | ELSEVIER | Published : 2020

Abstract

The known effects of aging on the brain and behavior include impaired cognition, increases in anxiety and depressive-like behaviors, and reduced locomotor activity. Environmental exposures and interventions also influence brain functions during aging. We investigated the effects of normal aging under controlled environmental conditions and in the absence of external interventions on locomotor activity, cognition, anxiety and depressive-like behaviors, immune function and hippocampal gene expression in C57BL/6 mice. Healthy mice at 4, 9, and 14 months of age underwent behavioral testing using an established behavioral battery, followed by cellular and molecular analysis using flow cytometry, ..

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Grants

Awarded by National Health and Medical Research Council Australia


Funding Acknowledgements

The presented work is supported by the National Health and Medical Research Council Australia (APP 1043771 to BTB). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.