Journal article

Proteomics and Imaging in Crohn's Disease: TAILS of Unlikely Allies

Barbara Mainoli, Simon Hirota, Laura E Edgington-Mitchell, Cathy Lu, Antoine Dufour

TRENDS IN PHARMACOLOGICAL SCIENCES | ELSEVIER SCIENCE LONDON | Published : 2020

Abstract

Crohn's disease (CD) is a chronic relapsing inflammatory bowel disease (IBD) that may be marked by debilitating symptoms of abdominal pain and obstruction. The etiology and pathogenesis of the disease are not fully understood, and treatment with corticosteroids, biologics, and surgical intervention are the usual therapeutic options. Diagnosis, disease activity, and therapeutic response are currently assessed by endoscopy, cross-sectional imaging, and biomarkers. However, challenges remain regarding the efficacy of the drugs and safety of these imaging techniques. There are also limitations with current clinical and laboratory tools for diagnosis, disease progression, and treatment response. ..

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Grants

Awarded by Natural Sciences and Engineering Research Council (NSERC)


Awarded by National Health and Medical Research Council of Australia (NHMRC)


Awarded by Australian Research Council (ARC)


Awarded by Priority-Driven Collaborative Cancer Research Young Investigator Award from Cure Cancer


Awarded by Cancer Australia


Funding Acknowledgements

A.D. and B.M. were supported by a Natural Sciences and Engineering Research Council (NSERC) Discovery Grant (DGECR-2019-00112). L.E,E-M. was supported by an Early Career Fellowship from the National Health and Medical Research Council of Australia (NHMRC, GNT1091636), a Grimwade Fellowship funded by the Russell and Mab Grimwade Miegunyah Fund at the University of Melbourne, a Discovery Early Career Researcher Award (DECRA) Fellowship from the Australian Research Council (ARC, DE180100418), and a Priority-Driven Collaborative Cancer Research Young Investigator Award from Cure Cancer and Cancer Australia (GNT1157171).