Journal article

A multi-national, multi-disciplinary Delphi consensus study on using omega-3 polyunsaturated fatty acids (n-3 PUFAs) for the treatment of major depressive disorder

Ta-Wei Guu, David Mischoulon, Jerome Sarris, Joseph Hibbeln, Robert K McNamara, Kei Hamazaki, Marlene P Freeman, Michael Maes, Yutaka J Matsuoka, RH Belmaker, Wolfgang Marx, Carmine Pariante, Michael Berk, Felice Jacka, Kuan-Pin Su

Journal of Affective Disorders | ELSEVIER | Published : 2020

Abstract

INTRODUCTION: Omega-3 polyunsaturated fatty acids (n-3 PUFAs) are recommended as an integrative treatment for major depressive disorder (MDD). In 2019, the International Society for Nutritional Psychiatry Research (ISNPR) developed the first practice guidelines for n-3 PUFA treatment of MDD. To strengthen these guidelines and enhance their clinical applicability, we synthesized the evidence and clinical experiences previously obtained through the Delphi methodology. METHODS: Nineteen statements covering five major domains in MDD treatment were formulated through internal meetings. Fourteen international experts were invited to participate in the web-based Delphi process that validated the st..

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Grants

Awarded by Ministry of Science and Technology, Taiwan


Awarded by National Health Research Institutes, Taiwan


Awarded by Higher Education Sprout Project by the Ministry of Education (MOE), Taiwan


Awarded by China Medical University, Taichung, Taiwan


Awarded by China Medical University Hospital, Taichung, Taiwan


Awarded by NHMRC Senior Principal Research Fellowship


Awarded by NHMRC Clinical Research Fellowship


Awarded by University of Macau, China


Funding Acknowledgements

The authors of this work were supported by the following grants: MOST 108-2320-B-039-048; 108-2314-B-039-016; MOST 108-2813-C-039-133-B; 106-2314-B-039-027-MY3; and 106-2314-B-039-027 from the Ministry of Science and Technology, Taiwan; NHRI-EX108-10528NI from the National Health Research Institutes, Taiwan; CMRCCMA-3 from Higher Education Sprout Project by the Ministry of Education (MOE), Taiwan; CMU108-SR-106 from the China Medical University, Taichung, Taiwan; and CRS-108-048, DMR-108-216 and DMR-109-102 from the China Medical University Hospital, Taichung, Taiwan. In addition, Michael Berk is supported by a NHMRC Senior Principal Research Fellowship (1059660 and APP1156072) and Jerome Sarris is supported by an NHMRC Clinical Research Fellowship (APP1125000). We thank Miss Yu-Chuan Chien from University of Macau, China (MYRG2018-00242-ICMS) for data collection and organization.