B cell immunodominance in primary hepatitis C virus infection
Nicholas A Brasher, Auda A Eltahla, Alexander Underwood, Irene Boo, Simone Rizzetto, Melanie R Walker, Chaturaka Rodrigo, Fabio Luciani, Lisa Maher, Heidi E Drummer, Nicodemus Tedla, Andrew R Lloyd, Rowena A Bull
Journal of Hepatology | ELSEVIER | Published : 2020
BACKGROUND & AIMS: Neutralising antibodies (NAbs) play a key role in clearance of HCV. NAbs have been isolated and mapped to several domains on the HCV envelope proteins. However, the immunodominance of these epitopes in HCV infection remains unknown, hindering efforts to elicit optimal epitope-specific responses. Furthermore, it remains unclear which epitope-specific responses are associated with broad NAb (bNAb) activity in primary HCV infection. The aim of this study was to define B cell immunodominance in primary HCV, and its implications on neutralisation breadth and clearance. METHODS: Using samples from 168 patients with primary HCV infection, the antibody responses targeted 2 immunod..View full abstract
Awarded by National Health and Medical Research Council of Australia (NHMRC)
Awarded by NHMRC
Research support for the HITS-p cohort includes grants from National Health and Medical Research Council of Australia (NHMRC) -Project Nos. 222887, 1146082, Partnership No. 1016351, and Program Nos. 510488 and 1053206. The HITS-c cohort was supported by the UNSW Hepatitis C Vaccine Initiative and NHMRC Project Grant No. 630483. The Kirby Institute is funded by the Australian Government Department of Health and Ageing. AAE, FL, HED, ARL and RAB are supported by NHMRC Research Fellowships (Numbers: 1130128, 1128416, 1043067, 1137587 and 1084706).