Neuraminidase Inhibitors and Hospital Length of Stay: A Meta-analysis of Individual Participant Data to Determine Treatment Effectiveness Among Patients Hospitalized With Nonfatal 2009 Pandemic Influenza A(H1N1) Virus Infection

S Venkatesan; PR Myles; KJ Bolton; SG Muthuri; T Al Khuwaitir; AP Anovadiya; E Azziz-Baumgartner; T Bajjou; M Bassetti; B Beovic; B Bertisch; I Bonmarin; R Booy; VH Borja-Aburto; H Burgmann; B Cao; J Carratala; T Chinbayar; C Cilloniz; JT Denholm; SR Dominguez; PAD Duarte; G Dubnov-Raz; S Fanella; Z Gao; P Gérardin; M Giannella; S Gubbels; J Herberg; AL Higuera Iglesias; PH Hoeger; XY Hu; QT Islam; MF Jiménez; G Keijzers; H Khalili; G Kusznierz; I Kuzman; E Langenegger; KB Lankarani; YS Leo; RP Libster; R Linko; F Madanat; E Maltezos; A Mamun; T Manabe; G Metan; A Mickiene; D Mikić; KGI Mohn; ME Oliva; M Ozkan; D Parekh; M Paul; BA Rath; S Refaey; AH Rodríguez; B Sertogullarindan; J Skręt-Magierło; A Somer; E Talarek; JW Tang; K To; D Tran; TM Uyeki; W Vaudry; T Vidmar; P Zarogoulidis; JS Nguyen-Van-Tam

Journal article

Neuraminidase Inhibitors and Hospital Length of Stay: A Meta-analysis of Individual Participant Data to Determine Treatment Effectiveness Among Patients Hospitalized With Nonfatal 2009 Pandemic Influenza A(H1N1) Virus Infection

S Venkatesan, PR Myles, KJ Bolton, SG Muthuri, T Al Khuwaitir, AP Anovadiya, E Azziz-Baumgartner, T Bajjou, M Bassetti, B Beovic, B Bertisch, I Bonmarin, R Booy, VH Borja-Aburto, H Burgmann, B Cao, J Carratala, T Chinbayar, C Cilloniz, JT Denholm Show all

Journal of Infectious Diseases | OXFORD UNIV PRESS INC | Published : 2020

DOI: 10.1093/infdis/jiz152

Abstract

BACKGROUND: The effect of neuraminidase inhibitor (NAI) treatment on length of stay (LoS) in patients hospitalized with influenza is unclear. METHODS: We conducted a one-stage individual participant data (IPD) meta-analysis exploring the association between NAI treatment and LoS in patients hospitalized with 2009 influenza A(H1N1) virus (A[H1N1]pdm09) infection. Using mixed-effects negative binomial regression and adjusting for the propensity to receive NAI, antibiotic, and corticosteroid treatment, we calculated incidence rate ratios (IRRs) and 95% confidence intervals (CIs). Patients with a LoS of <1 day and those who died while hospitalized were excluded. RESULTS: We analyzed data on 18 3..

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