A Current Perspective on Wound Healing and Tumour-Induced Angiogenesis
Jennifer A Flegg, Shakti N Menon, Helen M Byrne, DL Sean McElwain
Bulletin of Mathematical Biology | SPRINGER | Published : 2020
Angiogenesis, or capillary growth from pre-existing vasculature, is an essential component of several physiological processes, both vital and pathological. These include dermal wound healing and tumour growth that together pose some of the most significant challenges to healthcare systems worldwide. Over the last few decades, mathematical modelling has proven to be a valuable tool for unravelling the complex network of interactions that underlie such processes. Moreover, theoretical frameworks that describe some of the mechanical and chemical aspects of angiogenesis inherent in wound healing and tumour growth have revealed intriguing similarities between the two processes. In this review, we..View full abstract
Awarded by Australian Research Council
JAF would like to acknowledge funding from the Australian Research Council (DE160100227) that supported this work. SNM is supported by the IMSc Complex Systems Project (12th Plan). We would also like to thank Rocio A. Mince for help with the illustrated schematics.