Response of the Salmon Heart Transcriptome to Pancreas Disease: Differences Between High- and Low-Ranking Families for Resistance
NA Robinson, A Krasnov, E Burgerhout, H Johnsen, HK Moghadam, B Hillestad, ML Aslam, M Baranski, SA Boison
Scientific Reports | NATURE RESEARCH | Published : 2020
Pancreas disease caused by salmonid alphaviruses leads to severe losses in Atlantic salmon aquaculture. The aim of our study was to gain a better understanding of the biological differences between salmon with high and low genomic breeding values (H-gEBV and L-gEBV respectively) for pancreas disease resistance. Fish from H- and L-gEBV families were challenged by intraperitoneal injection of salmonid alphavirus or co-habitation with infected fish. Mortality was higher with co-habitation than injection, and for L- than H-gEBV. Heart for RNA-seq and histopathology was collected before challenge and at four- and ten-weeks post-challenge. Heart damage was less severe in injection-challenged H- th..View full abstract
Awarded by Research Council of Norway
The research was funded by the Research Council of Norway (project number 254880) and supported by the Norwegian Institute of Food, Fisheries and Aquaculture (Nofima). High throughput sequencing was performed by the Norwegian Sequencing Centre (www.sequencing.uio.no), a national technology platform hosted by the University of Oslo and Oslo University Hospital and supported by the "Functional Genomics" and "Infrastructure" programs of the Research Council of Norway and the South-eastern Regional Health Authorities.