Genetic deletion of mast cell serotonin synthesis prevents the development of obesity and insulin resistance.
Julian M Yabut, Eric M Desjardins, Eric J Chan, Emily A Day, Julie M Leroux, Bo Wang, Elizabeth D Crane, Wesley Wong, Katherine M Morrison, Justin D Crane, Waliul I Khan, Gregory R Steinberg
Nature Communications | Published : 2020
Obesity is linked with insulin resistance and is characterized by excessive accumulation of adipose tissue due to chronic energy imbalance. Increasing thermogenic brown and beige adipose tissue futile cycling may be an important strategy to increase energy expenditure in obesity, however, brown adipose tissue metabolic activity is lower with obesity. Herein, we report that the exposure of mice to thermoneutrality promotes the infiltration of white adipose tissue with mast cells that are highly enriched with tryptophan hydroxylase 1 (Tph1), the rate limiting enzyme regulating peripheral serotonin synthesis. Engraftment of mast cell-deficient mice with Tph1-/- mast cells or selective mast cell..View full abstract