MRI Reveals Human Brown Adipose Tissue Is Rapidly Activated in Response to Cold.
Stephan M Oreskovich, Frank J Ong, Basma A Ahmed, Norman B Konyer, Denis P Blondin, Elizabeth Gunn, Nina P Singh, Michael D Noseworthy, Francois Haman, Andre C Carpentier, Zubin Punthakee, Gregory R Steinberg, Katherine M Morrison
Journal of the Endocrine Society | Published : 2019
Context: In rodents, cold exposure induces the activation of brown adipose tissue (BAT) and the induction of intracellular triacylglycerol (TAG) lipolysis. However, in humans, the kinetics of supraclavicular (SCV) BAT activation and the potential importance of TAG stores remain poorly defined. Objective: To determine the time course of BAT activation and changes in intracellular TAG using MRI assessment of the SCV (i.e., BAT depot) and fat in the posterior neck region (i.e., non-BAT). Design: Cross-sectional. Setting: Clinical research center. Patients or Other Participants: Twelve healthy male volunteers aged 18 to 29 years [body mass index = 24.7 ± 2.8 kg/m2 and body fat percentage = 25.0%..View full abstract