Journal article

The distinctive neural circuitry of complex posttraumatic stress disorder during threat processing

Richard A Bryant, Kim L Felmingham, Gin Malhi, Elpiniki Andrew, Mayuresh S Korgaonkar

PSYCHOLOGICAL MEDICINE | CAMBRIDGE UNIV PRESS | Published : 2021

Abstract

BACKGROUND: There is controversy over the extent to which the new International Classification of Diseases (ICD-11) diagnosis of complex posttraumatic stress disorder (CPTSD) is distinct from posttraumatic stress disorder (PTSD). This study aimed to conduct the first investigation of distinctive neural processes during threat processing in CPTSD relative to PTSD. METHOD: This cross-sectional functional magnetic resonance study included 99 participants who met criteria for PTSD (PTSD = 32, CPTSD = 28) and 39 trauma-exposed controls. PTSD was assessed with the Clinician-Administered PTSD Scale (CAPS). CPTSD was assessed with an adapted version of the International Trauma Questionnaire. Neural ..

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Grants

Awarded by National Health and Medical Research Council


Funding Acknowledgements

The study was funded by the National Health and Medical Research Council (1073041). The funder had no role in study design, data collection or analysis, or report preparation.