Bioinspired surface modification of orthopedic implants for bone tissue engineering.
Chao Hu, Deepu Ashok, David R Nisbet, Vini Gautam
Biomaterials | Elsevier | Published : 2019
Biomedical implants have been widely used in various orthopedic treatments, including total hip arthroplasty, joint arthrodesis, fracture fixation, non-union, dental repair, etc. The modern research and development of orthopedic implants have gradually shifted from traditional mechanical support to a bioactive graft in order to endow them with better osteoinduction and osteoconduction. Inspired by structural and mechanical properties of natural bone, this review provides a panorama of current biological surface modifications for facilitating the interaction between medical implants and bone tissue and gives a future outlook for fabricating the next-generation multifunctional and smart implan..View full abstract
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Awarded by Australian Research Council, Australia
Awarded by Dementia Research Leadership Fellowship from the National Health and Medical Research Council, Australia
VG acknowledges the Discovery Early Career Researcher Award DE180100775 from the Australian Research Council, Australia. DRN was supported by Dementia Research Leadership Fellowship (GNT1135687) from the National Health and Medical Research Council, Australia. The authors declare no competing interests.