Journal article

Relationship of Established Cardiovascular Risk Factors and Peripheral Biomarkers on Cognitive Function in Adults at Risk of Cognitive Deterioration

Michelle MY Lai, Matthew J Sharman, David J Ames, Kathryn A Ellis, Kay L Cox, Graham Hepworth, Patricia Desmond, Elizabeth Cyarto, Ralph N Martins, Colin L Masters, Nicola T Lautenschlager

Journal of Alzheimer's Disease | IOS PRESS | Published : 2020


BACKGROUND: There is a paucity of information on the role of microvascular and inflammatory biomarkers in cognitive dysfunction. OBJECTIVE: This study sought to evaluate the relationships between established and a number of peripheral biomarkers on cognitive patterns in 108 older adults with memory complaints. METHODS: Participants in the AIBL Active study aged 60 years and older with at least one vascular risk factor and memory complaints completed a neuropsychological test battery and provided cross-sectional health data. Linear regression models adjusted for covariates examined associations between cognitive performance and a panel of vascular risk factors (Framingham cardiovascular score..

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Awarded by Australian National Health and Medical Research Council

Funding Acknowledgements

We thank the Australian Imaging Biomarker and Lifestyle Study of Ageing participants for their participation, the participating research staff at the National Aging Research Institute (NARI) and the Mental Health Research Institute (MHRI) for the collection of physical assessments and the administration of the study.This work is supported by a project grant from the Australian National Health and Medical Research Council awarded to NL, PMD, KC, DA, KE, MJS, and CM (ID: 1005492).