Antibody effector functions in malaria and other parasitic diseases: a few needles and many haystacks
Elizabeth H Aitken, Siddhartha Mahanty, Stephen J Rogerson
Immunology & Cell Biology | WILEY | Published : 2020
Many parasitic infections stimulate antibody responses in their mammalian hosts. The ability of these antibodies to protect against disease varies markedly. Research has revealed that functional properties of antibodies determine their role in protection against parasites. Investigations of antibodies against Plasmodium spp. have demonstrated a variety of functional activities, ranging from invasion inhibition and parasite growth inhibition to antibody-dependent cellular phagocytosis and antibody-dependent cellular cytotoxicity. These activities have been demonstrated with a large variety of parasite molecules at multiple life cycle stages, highlighting the importance of functional antibody ..View full abstract
SJR is supported by a Program Grant, and SJR and EHA by a Project Grant both from the National Health and Medical Research Council of Australia. Images were created with BioRender.