Impact of coronary revascularization and transmural extent of scar on regional left ventricular remodelling

Abstract

Aims: Transmural extent (TME) of myocardial scar, contractile reserve, and perfusion all predict improvement in regional myocardial function after coronary revascularization. We sought their association with regional remodelling after infarction. Methods and results: We studied 89 patients (age 62 ± 10 years) with left ventricular (LV) dysfunction, at least 1 month post infarction. Viability was identified by TME 60% uptake on delayed redistribution on TI-201 SPECT (single photon emission computed tomography). Coronary revascularization was performed in 36 patients. Regional LV end-diastolic volume (EDV) and end-systolic volume, and ejection fraction were measured with MRI at baseline and af..