Molecular mechanisms of protein-bound uremic toxin-mediated cardiac, renal and vascular effects: underpinning intracellular targets for cardiorenal syndrome therapy
Feby Savira, Ruth Magaye, Yue Hua, Danny Liew, David Kaye, Tom Marwick, Bing Hui Wang
Toxicology Letters | ELSEVIER IRELAND LTD | Published : 2019
Cardiorenal syndrome (CRS) remains a global health burden with a lack of definitive and effective treatment. Protein-bound uremic toxin (PBUT) overload has been identified as a non-traditional risk factor for cardiac, renal and vascular dysfunction due to significant albumin-binding properties, rendering these solutes non-dialyzable upon the state of irreversible kidney dysfunction. Although limited, experimental studies have investigated possible mechanisms in PBUT-mediated cardiac, renal and vascular effects. The ultimate aim is to identify relevant and efficacious targets that may translate beneficial outcomes in disease models and eventually in the clinic. This review will expand on deta..View full abstract
Awarded by National Health and Medical Research Council of Australia
This research was supported by National Health and Medical Research Council of Australia (Program Grant 1092642 and Project Grant 1087355).