Journal article

Impaired left atrial strain predicts abnormal exercise haemodynamics in heart failure with preserved ejection fraction

Fernando Telles, Shane Nanayakkara, Shona Evans, Hitesh C Patel, Justin A Mariani, Donna Vizi, Jeremy William, Thomas H Marwick, David M Kaye



BACKGROUND: Elevated left atrial (LA) pressure, particularly during exercise, is associated with symptomatic status and survival in patients with heart failure with preserved ejection fraction (HFpEF). We aimed to characterize the contribution of abnormal LA mechanical properties to exercise haemodynamics in HFpEF. METHODS AND RESULTS: Simultaneous echocardiography and right heart catheterization were performed in 71 subjects with left ventricular ejection fraction ≥ 50% referred for assessment of exertional dyspnoea. According to haemodynamic evaluation, 49 patients were diagnosed with HFpEF [pulmonary capillary wedge pressure (PCWP) ≥ 15 mmHg at rest and/or ≥ 25 mmHg at maximal exertion] a..

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Awarded by National Heart Foundation of Australia

Funding Acknowledgements

Shane Nanayakkara is supported by a Health Professional Scholarship (101116) from the National Heart Foundation of Australia and a Bright Sparks grant from the Baker Heart and Diabetes Institute. David M. Kaye is supported by a grant from the National Health and Medical Research Council of Australia. The Baker Heart and Diabetes Institute is supported by a Victorian Government OIS Grant.