Left Ventricular Global Longitudinal Strain (GLS) Is a Superior Predictor of All-Cause and Cardiovascular Mortality When Compared to Ejection Fraction in Advanced Chronic Kidney Disease
Rathika Krishnasamy, Nicole M Isbel, Carmel M Hawley, Elaine M Pascoe, Matthew Burrage, Rodel Leano, Brian A Haluska, Thomas H Marwick, Tony Stanton
PLOS ONE | PUBLIC LIBRARY SCIENCE | Published : 2015
BACKGROUND: Echocardiographic global longitudinal strain (GLS) is increasingly recognised as a more effective technique than conventional ejection fraction (EF) in detecting subtle changes in left ventricular (LV) function. This study investigated the prognostic value of GLS over EF in patients with advanced Chronic Kidney Disease (CKD). METHODS: The study included 183 patients (57% male, 63% on dialysis) with CKD stage 4, 5 and 5Dialysis (D). 112 (61%) of patients died in a follow up of 7.8 ± 4.4 years and 41% of deaths were due to cardiovascular (CV) disease. GLS was calculated using 2-dimensional speckle tracking and EF was measured using Simpson's biplane method. Cox proportional hazard ..View full abstract
Funding: This study was supported in part by a grant from the National Health and Medical Research Council of Australia. There are no additional funding sources for this study.