Journal article
Prediction of hospital outcome in septic shock: A prospective comparison of tissue Doppler and cardiac biomarkers
DJ Sturgess, TH Marwick, C Joyce, C Jenkins, M Jones, P Masci, D Stewart, B Venkatesh
Critical Care | BMC | Published : 2010
DOI: 10.1186/cc8931
Open access
Abstract
Introduction: Diastolic dysfunction as demonstrated by tissue Doppler imaging (TDI), particularly E/e' (peak early diastolic transmitral/peak early diastolic mitral annular velocity) is common in critical illness. In septic shock, the prognostic value of TDI is undefined. This study sought to evaluate and compare the prognostic significance of TDI and cardiac biomarkers (B-type natriuretic peptide (BNP); N-terminal proBNP (NTproBNP); troponin T (TnT)) in septic shock. The contribution of fluid management and diastolic dysfunction to elevation of BNP was also evaluated.Methods: Twenty-one consecutive adult patients from a multidisciplinary intensive care unit underwent transthoracic echocardi..
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Funding Acknowledgements
Mr Goce Dimeski (Chemical Pathology, Princess Alexandra Hospital, Queensland Health Pathology Service, Ipswich Road, Brisbane, Australia) assisted with advice regarding biochemical assay techniques. Dr Elaine Beller (School of Population Health, The University of Queensland, Princess Alexandra Hospital, Brisbane, Australia) assisted with advice regarding final statistical analysis. This study was conducted with the support of grants from the Australian and New Zealand College of Anaesthetists. This study was performed at the Department of Intensive Care and The University of Queensland, Princess Alexandra Hospital, Ipswich Road, Brisbane, 4102, Australia.