Journal article

Ventricular hypertrophy and left atrial dilatation persist and are associated with reduced survival after valve replacement for aortic stenosis

Jocelyn M Beach, Tomislav Mihaljevic, Jeevanantham Rajeswaran, Thomas Marwick, Samuel T Edwards, Edward R Nowicki, James Thomas, Lars G Svensson, Brian Griffin, A Marc Gillinov, Eugene H Blackstone

The Journal of Thoracic and Cardiovascular Surgery | MOSBY-ELSEVIER | Published : 2014


OBJECTIVES: We sought to understand the factors modulating left heart reverse remodeling after aortic valve replacement, the relationship between the preoperative symptoms and modulators of left heart remodeling, and their influence on long-term survival. METHODS: From October 1991 to January 2008, 4264 patients underwent primary aortic valve replacement for aortic stenosis. Changes in the time course of left ventricular reverse remodeling were assessed using 5740 postoperative transthoracic echocardiograms from 3841 patients. RESULTS: Left ventricular hypertrophy rapidly declined after surgery, from 137 ± 42 g/m(2) preoperatively to 115 ± 27 by 2 years and remained relatively constant but g..

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Awarded by National Space Biomedical Research Institute through NASA

Funding Acknowledgements

This work was supported by awards from the American Heart Association (to J.M.B.). It was also supported in part by the Donna and Ken Lewis Chair in Cardiothoracic Surgery (to T.M.); the Charles and Lorraine Moore Endowed Chair in Cardiovascular Imaging (to J.T.); the National Space Biomedical Research Institute through NASA NCC 9-58 (to J.T.); the Judith Dion Pyle Endowed Chair in Heart Valve Research (to A.M.G.); the John and Rosemary Brown Endowed Chair in Cardiovascular Medicine (to B.G.); and the Kenneth Gee and Paula Shaw, PhD, Chair in Heart Research (to E.H.B.).