Cardiorespiratory Fitness Is Independently Associated with 25-Hydroxyvitamin D in Chronic Kidney Disease
William G Petchey, Erin J Howden, David W Johnson, Carmel M Hawley, Thomas Marwick, Nicole M Isbel
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY | AMER SOC NEPHROLOGY | Published : 2011
BACKGROUND AND OBJECTIVES: Vitamin D is an established important contributor to muscle function and aerobic metabolism. Hypovitaminosis D is highly prevalent in CKD patients and is associated with increased cardiovascular (CV) mortality via unknown mechanisms. Because aerobic-exercise capacity strongly predicts future CV events, we hypothesized that vitamin D status could be linked to CV outcomes via an effect on maximum aerobic-exercise capacity in patients with CKD and that this effect may be mediated in part via its actions on muscle strength and functional ability. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Baseline demographic, anthropometric, and biochemical data were collected in ..View full abstract
W.P. has previously received funding from Roche Pharmaceuticals Pty and scholarships from the National Health and Medical Research Council (NHMRC)-funded Centre for Clinical Research Excellence (CCRE), Cardiovascular Disease and Metabolic Disorders, University of Queensland. Study resources were supplied by CCRE at the University of Queensland. Part of this work was presented at the 12<SUP>th</SUP> Asian-Pacific Congress of Nephrology, Seoul, June 5 through 8, 2010.