Association of Myocardial Deformation With Mortality Independent of Myocardial Ischemia and Left Ventricular Hypertrophy

Abstract

OBJECTIVES: The aim of this study was to investigate the relative contributions of left ventricular hypertrophy (LVH) and myocardial ischemia to the association between abnormal myocardial deformation during dobutamine stress echocardiography (DSE) and mortality. BACKGROUND: Both left ventricular hypertrophy (LVH) and myocardial ischemia are known to convey a significant adverse prognostic impact. In addition, myocardial deformation is an independent predictor of outcome in patients undergoing DSE. The mechanism of this association, however, is undefined. METHODS: We studied 223 consecutive individuals with normal resting LV function undergoing DSE. The LV mass was indexed to height (g/m(2.7..