Rheumatoid arthritis: links with cardiovascular disease and the receptor for advanced glycation end products.
Lisa Carroll, Suad Hannawi, Thomas Marwick, Ranjeny Thomas
Wien Med Wochenschr | Published : 2006
Cardiovascular (CV) disease is increased in patients with chronic inflammatory disease, including rheumatoid arthritis (RA). Furthermore it has become clear at a pathophysiological level, that atherosclerosis has striking similarities with autoimmune disease. This realization has come at a time of paradigm shift in how rheumatologists manage RA, with the availability of biological agents targeting key inflammatory cytokines. This review will focus on the possible causes of increased vascular disease in RA, including the role of traditional CV risk factors. Mechanisms potentially at play, such as C-reactive protein (CRP), altered coagulation, and cyclooxygenase (COX)-2 inhibitors will be cove..View full abstract