Journal article

Targeting GM-CSF for collagenase-induced osteoarthritis pain and disease in mice

KM-C Lee, V Prasad, A Achuthan, AJ Fleetwood, JA Hamilton, AD Cook

Osteoarthritis and Cartilage | ELSEVIER SCI LTD | Published : 2020

Abstract

OBJECTIVES: Pharmacological options for treating osteoarthritis (OA) are limited and alternative treatments are required. Given the clinical data indicating that granulocyte macrophage-colony stimulating factor (GM-CSF) may be a therapeutic target in human OA, we evaluated different treatment regimens with a neutralizing anti-GM-CSF monoclonal antibody (mAb) in an experimental OA model to determine their effectiveness on amelioration of pain and disease. METHODS: The collagenase-induced osteoarthritis (CiOA) model was induced in C57BL/6 mice, followed by different treatment regimens of anti-GM-CSF mAb or isotype control. Anti-CCL17 mAb treatment was also administered continually during the l..

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