Journal article

The characterization of Abelson helper integration site-1 in skeletal muscle and its links to the metabolic syndrome

Matthew J Prior, Victoria C Foletta, Jeremy B Jowett, David H Segal, Melanie A Carless, Joanne E Curran, Tom D Dyer, Eric K Moses, Andrew J McAinch, Nicky Konstantopoulos, Kiymet Bozaoglu, Greg R Collier, David Cameron-Smith, John Blangero, Ken R Walder

METABOLISM-CLINICAL AND EXPERIMENTAL | W B SAUNDERS CO-ELSEVIER INC | Published : 2010

Abstract

The human Abelson helper integration site-1 (AHI1) gene is associated with both neurologic and hematologic disorders; however, it is also located in a chromosomal region linked to metabolic syndrome phenotypes and was identified as a type 2 diabetes mellitus susceptibility gene from a genomewide association study. To further define a possible role in type 2 diabetes mellitus development, AHI1 messenger RNA expression levels were investigated in a range of tissues and found to be highly expressed in skeletal muscle as well as displaying elevated levels in brain regions and gonad tissues. Further analysis in a rodent polygenic animal model of obesity and type 2 diabetes mellitus identified inc..

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Grants

Awarded by US National Institute of Mental Health


Awarded by NATIONAL HEART, LUNG, AND BLOOD INSTITUTE


Awarded by NATIONAL INSTITUTE OF MENTAL HEALTH


Funding Acknowledgements

We thank Petra Gran, Marissa Trenerry, and Rani Watts for their efforts in preparing and analyzing the clinical samples; and we are grateful to the participants in the San Antonio Family Heart Study. This study was funded by Verva Pharmaceuticals and by the Molecular Medicine and Nutrition Cluster, Deakin University. The SOLAR statistical genetics computer package is supported by a grant from the US National Institute of Mental Health (MH059490).