Journal article

Impact of DISC1 variation on neuroanatomical and neurocognitive phenotypes

MA Carless, DC Glahn, MP Johnson, JE Curran, K Bozaoglu, TD Dyer, AM Winkler, SA Cole, L Almasy, JW MacCluer, R Duggirala, EK Moses, HHH Goering, J Blangero

Molecular Psychiatry | NATURE PUBLISHING GROUP | Published : 2011

Abstract

Although disrupted in schizophrenia 1 (DISC1) has been implicated in many psychiatric disorders, including schizophrenia, bipolar disorder, schizoaffective disorder and major depression, its biological role in these disorders is unclear. To better understand this gene and its role in psychiatric disease, we conducted transcriptional profiling and genome-wide association analysis in 1232 pedigreed Mexican-American individuals for whom we have neuroanatomic images, neurocognitive assessments and neuropsychiatric diagnoses. SOLAR was used to determine heritability, identify gene expression patterns and perform association analyses on 188 quantitative brain-related phenotypes. We found that the ..

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Grants

Awarded by NIMH


Awarded by NHLBI program


Awarded by National Center for Research Resources, National Institutes of Health


Awarded by NATIONAL CENTER FOR RESEARCH RESOURCES


Awarded by NATIONAL HEART, LUNG, AND BLOOD INSTITUTE


Awarded by NATIONAL INSTITUTE OF MENTAL HEALTH


Funding Acknowledgements

Financial support for this study was provided by NIMH grants MH0708143 (PI: DC Glahn), MH078111 (PI: J Blangero) and MH083824 (PI: DC Glahn). SOLAR is supported by NIMH grant MH59490 (PI: J Blangero). Collection of family data and blood samples in the San Antonio Family Heart Study was supported by NHLBI program project grant P01 HL045522 (PI: J Blangero). We would like to thank the Azar and Shepperd families for their support of the transcriptional profiling. This investigation was conducted in facilities constructed with support from Research Facilities Improvement Program Grant Number C06 RR017515 from the National Center for Research Resources, National Institutes of Health.