Data-Driven Modelling of the Inositol Trisphosphate Receptor (IP3R) and its Role in Calcium-Induced Calcium Release (CICR)

Abstract

We review the current state of the art of data-driven modelling of the inositol trisphosphate receptor ($$\text {IP}_3\text {R}$$). After explaining that the $$\text {IP}_3\text {R}$$ plays a crucial role as a central regulator in calcium dynamics, several sources of relevant experimental data are introduced. Single ion channels are best studied by recording single-channel currents under different ligand concentrations via the patch-clamp technique. The particular relevance of modal gating, the spontaneous switching between different levels of channel activity that occur even at constant ligand concentrations, is highlighted. In order to investigate the intera..