Reduced Exercise Capacity in Diabetes Mellitus Is Not Associated with Impaired Deformation or Twist

TJ Roberts; JF Barros-Murphy; AT Burns; RJ MacIsaac; AI MacIsaac; DL Prior; A La Gerche

Journal article

Reduced Exercise Capacity in Diabetes Mellitus Is Not Associated with Impaired Deformation or Twist

TJ Roberts, JF Barros-Murphy, AT Burns, RJ MacIsaac, AI MacIsaac, DL Prior, A La Gerche

Journal of the American Society of Echocardiography | MOSBY-ELSEVIER | Published : 2020

DOI: 10.1016/j.echo.2019.11.012

Abstract

Background: Exercise capacity is frequently reduced in people with diabetes mellitus (DM) and may be due to subclinical cardiac dysfunction. Speckle-tracking echocardiography is now widely available; however, the clinical utility and significance of left ventricular (LV) strain and twist parameters remain uncertain. We hypothesized that LV strain and twist would be reduced in DM subjects during exercise. Methods: Adults with type 1 or type 2 DM and age- and sex-matched controls performed cardiopulmonary exercise testing (VO2 peak) and supine bicycle exercise echocardiography. Detailed echocardiographic assessment of biventricular function was performed at baseline and repeated during increme..

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University of Melbourne Researchers

Andrew Burns Author

Richard MacIsaac Author

Andrew MacIsaac Author

David Prior Author

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Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

This study was funded by the National Heart Foundation of Australia (Grant-in-Aid G 12M 6396). A.L.G. is supported by a Career Development Fellowship from the National Health and Medical Research Council (NHMRC 1089039) and a Future Leaders Fellowship from the National Heart Foundation (NHF 100409) of Australia.