Mucoadhesive thin films for the simultaneous delivery of microbicide and anti-inflammatory drugs in the treatment of periodontal diseases
Sim Yee Lim, Mali Dafydd, JieJi Ong, Launa A Ord-McDermott, Emma Board-Davies, Kirsty Sands, David Williams, Alastair J Sloan, Charles M Heard
International Journal of Pharmaceutics | ELSEVIER | Published : 2020
There is an unmet clinical need for new products to address the high percentage of the populous who present with periodontal diseases. Drug dose retention at the point of application would facilitate sustained release and more efficacious treatments. The aim of this study was to evaluate mucoadhesive polymeric thin films for simultaneous in situ delivery chlorhexidine and anti-inflammatory and analgesic drugs. Mucoadhesive thin films were prepared using a polymer mixture containing chlorhexidine (25 mg) ± diclofenac sodium (10 and 50 mg), and lidocaine hydrochloride (10 mg) or betamethasone dipropionate (10 and 50 mg). The films were assessed for in vitro drug release and localised tissue de..View full abstract
Awarded by Medical Research Council Proximity to Discovery, United Kingdom
Awarded by Welsh Government Life Sciences Bridging Fund -Pathfinder grant, United Kingdom
We gratefully acknowledge that this work was supported by: 1. Medical Research Council Proximity to Discovery as part of programme grant MC_PC_14132, United Kingdom 2. Welsh Government Life Sciences Bridging Fund -Pathfinder grant ID LSBF/R5-009, United Kingdom 3. Cardiff Institute of Tissue Engineering and Repair (CITER) summer research bursary, United Kingdom.