Journal article

Elucidating the cellular actions of demineralised dentine matrix extract on a clonal dental pulp stem cell population in orchestrating dental tissue repair

Chi P Lee, John S Colombo, Wayne Nishio Ayre, Alastair J Sloan, Rachel J Waddington

JOURNAL OF TISSUE ENGINEERING | SAGE PUBLICATIONS INC | Published : 2015

Abstract

Bioactive growth factors identified within the extracellular matrix of dentine have been proposed roles in regulating the naturally inherent regenerative dentine formation seen in teeth in response to trauma and infection, which may also be harnessed for novel clinical treatments in augmenting mineralised tissue repair. This study examined the specific biological action of demineralised dentine matrix extract on a clonal population of dental pulp stem cells in stimulating the prerequisite stages of wound healing associated with mineralised tissue repair. A clonal dental pulp stem cell population with sustained proliferative capacity and multi-potentiality towards osteogenic, adipogenic and c..

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University of Melbourne Researchers

Grants

Awarded by Wales Office for Research and Development


Awarded by Medical Research Council United Kingdom


Awarded by Medical Research Council


Funding Acknowledgements

This work was supported by the Wales Office for Research and Development (RFSSA07/3/005) and the Medical Research Council United Kingdom (GO900954).