Journal article
Liposomal Delivery of Demineralized Dentin Matrix for Dental Tissue Regeneration
Genevieve E Melling, John S Colombo, Steven J Avery, Wayne Nishio Ayre, Samuel L Evans, Rachel J Waddington, Alastair J Sloan
TISSUE ENGINEERING PART A | MARY ANN LIEBERT, INC | Published : 2018
Abstract
Current dental restorations have short longevity, and consequently, there is a need for novel tissue engineering strategies that aim to regenerate the dentin-pulp complex. Dentin matrix contains a myriad of bioactive growth factors and extracellular matrix proteins associated with the recruitment, proliferation, and differentiation of dental pulp progenitor cells. In this study, we show that demineralized dentin matrix (DDM), from noncarious dentine, can be encapsulated into liposomes for delivery to dental tissue to promote regeneration. Liposomes were formulated to encapsulate 0-100 μg/mL DDM, lysed with Triton X, and used in vascular endothelial growth factor (VEGF) and transforming growt..
View full abstractGrants
Awarded by MRC research grant
Awarded by MRC
Awarded by Health and Care Research Wales
Awarded by Medical Research Council
Awarded by The Dunhill Medical Trust
Funding Acknowledgements
This work was supported by Medical Research Council (MRC) UK Regenerative Medicine Platform, Acellular Approaches for therapeutic delivery Hub Partnership award and a MRC research grant (G0900954).