Tissue culture models and approaches for dental tissue regeneration

Abstract

The development of alternative treatment modalities for the management of significant dental tissue disease or trauma, such as caries, dentinal fractures, periodontal disease or obtaining biological evidence to support current clinical treatment regimes is hampered by the limitations of laboratory model systems currently available for the study of dental tissue repair. In vivo experimentation is always the gold standard in elucidating tissue regenerative processes that occur during dental tissue and bone repair, or tissue responses to new interventions. Currently, in vivo models using significant numbers of rodents and primates, along with in vitro cell culture systems using rodent cells and..