Journal article
Growth factor liberation and DPSC response following dentine conditioning
L Sadaghiani, HB Gleeson, S Youde, RJ Waddington, CD Lynch, AJ Sloan
Journal of Dental Research | SAGE PUBLICATIONS INC | Published : 2016
Abstract
Liberation of the sequestrated bioactive molecules from dentine by the action of applied dental materials has been proposed as an important mechanism in inducing a dentinogenic response in teeth with viable pulps. Although adhesive restorations and dentine-bonding procedures are routinely practiced, clinical protocols to improve pulp protection and dentine regeneration are not currently driven by biological knowledge. This study investigated the effect of dentine (powder and slice) conditioning by etchants/conditioners relevant to adhesive restorative systems on growth factor solubilization and odontoblast-like cell differentiation of human dental pulp progenitor cells (DPSCs). The agents in..
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Awarded by Medical Research Council
Funding Acknowledgements
We thank Wendy Rowe and Maria Stack for technical support and Xiaoqing Wei for sharing knowledge with respect to this study. This study was supported by the following award and prizes: 3M ESPE/Oral and Dental Research Trust Dental Biomaterials Award (2008), the Academy of Operative Dentistry European Section Research Prize (2010), and the British Society for Oral and Dental Research GSK-MINTIG Prize (2013). The authors declare no potential conflicts of interest with respect to the authorship and/or publication of this article.