`Pre-prosthetic use of poly(lactic-co-glycolic acid) membranes treated with oxygen plasma and TiO2 nanocomposite particles for guided bone regeneration processes'
Gabriel Castillo-Dali, Raquel Castillo-Oyaguee, Antonia Terriza, Jean-Louis Saffar, Antonio Batista-Cruzado, Christopher D Lynch, Alastair J Sloan, Jose-Luis Gutierrez-Perez, Daniel Torres-Lagares
Journal of Dentistry | ELSEVIER SCI LTD | Published : 2016
OBJECTIVES: Guided bone regeneration (GBR) processes are frequently necessary to achieve appropriate substrates before the restoration of edentulous areas. This study aimed to evaluate the bone regeneration reliability of a new poly-lactic-co-glycolic acid (PLGA) membrane after treatment with oxygen plasma (PO2) and titanium dioxide (TiO2) composite nanoparticles. METHODS: Circumferential bone defects (diameter: 10mm; depth: 3mm) were created on the parietal bones of eight experimentation rabbits and were randomly covered with control membranes (Group 1: PLGA) or experimental membranes (Group 2: PLGA/PO2/TiO2). The animals were euthanized two months afterwards, and a morphologic study was th..View full abstract
This study is supported by the research project P09CTS 5189. The authors would like to thank all of the scientific institutions named in this paper for their important collaboration in this investigation. We would also like to specially thank the laboratory technicians of the University of Paris Descartes for their valuable help during the study. Finally, the authors are grateful for the constructive insights of the reviewers.