Journal article

Oral Mucosal Lamina Propria-Progenitor Cells Exert Antibacterial Properties via the Secretion of Osteoprotegerin and Haptoglobin

Emma Board-Davies, Rachael Moses, Alastair Sloan, Phil Stephens, Lindsay C Davies



UNLABELLED: The oral cavity possesses a diverse microflora, yet recurrent infections within healthy individuals are rare. Wound healing within the buccal mucosa is preferential, potentially because of the presence of oral mucosal lamina propria-progenitor cells (OMLP-PCs). In addition to their multipotency, OMLP-PCs demonstrate potent immunosuppressive properties. The present study investigated whether OMLP-PCs possess antibacterial properties, directly interacting with microorganisms and contributing to the maintenance of a balanced oral microflora. Gram-positive and -negative bacteria were cocultured with OMLP-PCs, buccal mucosal fibroblasts, or their respective conditioned media (CM). Bac..

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Awarded by Medical Research Council

Awarded by Health and Care Research Wales

Funding Acknowledgements

This work was funded by Cardiff University, the Medical Research Council (Grant G0901562), Cardiff Institute of Tissue Engineering and Repair, and the Welsh Livery Guild. Buccal mucosal biopsy samples were kindly obtained from patients undergoing routine oral surgery by Andrew Cronin, Consultant Oral and Maxillofacial Surgeon (Cardiff and Vale University Health Board, Cardiff, U.K.). The present work is subjected to patent filing (patent application nos. PCT/GB2009/001443, AU2009259053, EP09761964.7, CN200980122121.0, JP501125275, HK1155775, and US12/997,363).