Journal article

Osteogenic Potential of Bone Marrow Stromal Cells on Smooth, Roughened, and Tricalcium Phosphate-Modified Titanium Alloy Surfaces

John S Colombo, Albert Carley, Garry JP Fleming, St John Crean, Alastair J Sloan, Rachel J Waddington

International Journal of Oral and Maxillofacial Implants | QUINTESSENCE PUBLISHING CO INC | Published : 2012


PURPOSE: This study investigated the influence of smooth, roughened, and tricalcium phosphate (TCP)-coated roughened titanium-aluminum-vanadium (Ti-6Al-4V) surfaces on the osteogenic potential of rat bone marrow stromal cells (BMSCs). METHODS: Machined smooth (MS), grit-blasted roughened (MT), and roughened surfaces coated with TCP were prepared from Ti-6Al-4V. Plastic surfaces were used as a control. Surface topography and chemical characteristics were determined. Cell attachment, morphology, proliferation, and temporal expression of mRNA and protein markers associated with bone healing were examined. RESULTS: Roughness values were 0.09 ± 0.02 Μm, 2.71 ± 0.24 Μm, and 6.08 ± 0.62 Μm for MS, ..

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