Journal article

S100 and cytokine expression in caries

JL McLachlan, AJ Sloan, AJ Smith, G Landini, PR Cooper

Infection and Immunity | AMER SOC MICROBIOLOGY | Published : 2004


The molecular immune response of the pulpal tissue during chronic carious infection is poorly characterized. Our objective was to examine the expression of potential molecular mediators of pulpal inflammation, correlate their levels with disease severity, and determine the cellular localization of key molecules. Results indicated that there was significantly increased transcriptional activity in carious compared to healthy pulp, and the increase correlated positively with disease severity. Semiquantitative reverse transcriptase PCR analysis in 10 carious and 10 healthy pulpal tissue samples of the S100 family members S100A8, S100A9, S100A10, S100A12, and S100A13; the cytokines tumor necrosis..

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University of Melbourne Researchers