Journal article

PGRMC1 phosphorylation and cell plasticity 1: glycolysis, mitochondria, tumor growth

Bashar Thejer, Partho Adhikary, Amandeep Kaur, Sarah Teakel, Ashleigh Van Oosterum, Ishith Seth, Marina Pajic, Kate Hannan, Megan Pavy, Perlita Poh, Jalal Jazayeri, Thiri Zaw, Dana Pascovici, Marina Ludescher, Michael Pawlak, Juan Cassano, Lynne Turnbull, Mitra Jazayeri, Alexander James, Craig Coorey Show all

Published : 2019

Abstract

SUMMARY Progesterone Receptor Membrane Component 1 (PGRMC1) is expressed in many cancer cells, where it is associated with detrimental patient outcomes. It contains phosphorylated tyrosines which evolutionarily preceded deuterostome gastrulation and tissue differentiation mechanisms. Here, we demonstrate that manipulating PGRMC1 phosphorylation status in MIA PaCa-2 (MP) cells imposes broad pleiotropic effects. Relative to parental cells over-expressing hemagglutinin-tagged wild-type (WT) PGRMC1-HA, cells expressing a PGRMC1-HA-S57A/S181A double mutant (DM) exhibited reduced levels of proteins involved in energy metabolism and mitochondrial function, and altered glucose metabolism suggesting ..

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