Journal article

The effects of ulimorelin, a ghrelin agonist, on liquid gastric emptying and colonic transit in humans

Joyce James, Stuart Mair, Walter Doll, Erik Sandefer, David Wurtman, Alan Maurer, Adam M Deane, M Scott Harris

Neurogastroenterology & Motility | WILEY | Published : 2020

Abstract

BACKGROUND: Ulimorelin, a small molecule ghrelin agonist and prokinetic agent, was effective in animal models of gastroparesis and delayed transit. However, employing once daily administration, it failed in clinical trials of postoperative ileus (POI), a condition in which colonic motility recovers last. The aim of this study was to evaluate drug dosing and regional differences in drug activity between stomach and colon. METHODS: Gastric emptying was assessed by scintigraphy in healthy adults at single doses of 600-1200 µg kg-1 and multiple doses of 80-600 µg kg-1 Q8H for 7 days. Colonic motility was assessed by 7-region scintigraphic analysis at a dose of 600 µg kg-1 for 2 days. The primary..

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