Granulocyte-Macrophage Colony Stimulating Factor As an Indirect Mediator of Nociceptor Activation and Pain
Damini Tewari, Andrew D Cook, Ming-Chin Lee, Anne D Christensen, Andrew Croxford, Burkhard Becher, Daniel Poole, Pradeep Rajasekhar, Nigel Bunnett, Julia E Smith, John A Hamilton, Stephen B McMahon
The Journal of Neuroscience | SOC NEUROSCIENCE | Published : 2020
The interaction between the immune system and the nervous system has been at the center of multiple research studies in recent years. Whereas the role played by cytokines as neuronal mediators is no longer contested, the mechanisms by which cytokines modulate pain processing remain to be elucidated. In this study, we have analyzed the involvement of granulocyte-macrophage colony stimulating factor (GM-CSF) in nociceptor activation in male and female mice. Previous studies have suggested GM-CSF might directly activate neurons. However, here we established the absence of a functional GM-CSF receptor in murine nociceptors, and suggest an indirect mechanism of action, via immune cells. We report..View full abstract
Awarded by National Health and MedicalResearch Council of Australia
This work was supported by the Wellcome trust Senior Investigator Award to S.B.M., GlaxoSmith-Kline, and by Grant 1043147 from theNational Health and MedicalResearch Council of Australia. We thank Dr. Franziska Denk for advice on accessing publicly available RNA-seq data. Julia E. Smith is an employee of GSK.