Journal article

Propagation-Based Phase-Contrast CT of the Breast Demonstrates Higher Quality Than Conventional Absorption-Based CT Even at Lower Radiation Dose

Seyedamir Tavakoli Taba, Benedicta D Arhatari, Yakov I Nesterets, Ziba Gadomkar, Sheridan C Mayo, Darren Thompson, Jane Fox, Beena Kumar, Zdenka Prodanovic, Daniel Hausermann, Anton Maksimenko, Christopher Hall, Matthew Dimmock, Konstantin M Pavlov, Darren Lockie, Masoumeh Gity, Andrew Peele, Harry M Quiney, Sarah Lewis, Timur E Gureyev Show all

Academic Radiology | ELSEVIER SCIENCE INC | Published : 2021

Abstract

RATIONALE AND OBJECTIVES: Propagation-based phase-contrast CT (PB-CT) is an advanced X-ray imaging technology that exploits both refraction and absorption of the transmitted X-ray beam. This study was aimed at optimizing the experimental conditions of PB-CT for breast cancer imaging and examined its performance relative to conventional absorption-based CT (AB-CT) in terms of image quality and radiation dose. MATERIALS AND METHODS: Surgically excised breast mastectomy specimens (n = 12) were scanned using both PB-CT and AB-CT techniques under varying imaging conditions. To evaluate the radiological image quality, visual grading characteristics (VGC) analysis was used in which 11 breast specia..

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Grants

Awarded by National Health and Medical Research Council (NHMRC), Australia


Funding Acknowledgements

This work was supported by National Health and Medical Research Council (NHMRC), Australia [grant number APP1138283].