Interleukin-17A Serves a Priming Role in Autoimmunity by Recruiting IL-1β-Producing Myeloid Cells that Promote Pathogenic T Cells

Abstract

Experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis, is an autoimmune disease in which the cytokine IL-17A is thought to mediate CNS tissue damage. McGinley et al. report a new role for IL-17A in mobilizing innate immune cells that secrete IL-1β, an inflammatory cytokine that primes encephalitogenic T cells.