Journal article

The QuantiFERON Monitor (R) assay is predictive of infection post allogeneic hematopoietic cell transplantation

Abby P Douglas, Lijia Yu, Vijaya Sundararajan, Jeff Szer, David Ritchie, Monica A Slavin, Joe Sasadeusz, Kumar Visvanathan

Transplant Infectious Disease | WILEY | Published : 2020

Abstract

INTRODUCTION: Following allogeneic hematopoietic stem cell transplantation (alloHCT), excessive immunosuppression can be complicated by infection, while inadequate immunosuppression can result in graft-vs-host disease (GVHD). An accurate method to assess overall immune status post HCT is lacking. The QuantiFERON Monitor® (QFM) assay measures interferon gamma (IFN-γ) release from whole blood following incubation with both innate (Toll-like receptor 7, TLR7) and adaptive (CD3 antibody) stimulants and may result in a more complete assessment of the immune system. METHODS: Whole blood samples were prospectively collected from alloHCT recipients at conditioning followed by days 10, 30, 60, 90, 12..

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