Impact of disease stage on the performance of strain markers in the prediction of atrial fibrillation
Satish Ramkumar, Faraz Pathan, Hiroshi Kawakami, Ayame Ochi, Hong Yang, Elizabeth L Potter, Thomas H Marwick
INTERNATIONAL JOURNAL OF CARDIOLOGY | ELSEVIER IRELAND LTD | Published : 2021
BACKGROUND: Assessing atrial fibrillation (AF) risk may be useful in primary prevention (PP; people with risk factors) and secondary prevention (SP; eg. embolic stroke of unknown source). We sought whether disease stage influenced the prediction of AF by echocardiography. METHODS: We compared a PP cohort (351 community-based participants ≥65 years with ≥1 risk factor for AF) and a SP cohort (453 patients after transient ischemic attack or stroke). LV global longitudinal strain (GLS) and left atrial reservoir strain (LARS) were measured from DICOM images. AF was diagnosed by 12 lead ECG, Holter or by single lead monitor over median follow-up of 22 months (PP) and 35 months (SP). The clinical ..View full abstract
Awarded by National Health and Medical Research Council, Canberra, Australia
S.R is supported by a research scholarship by the National Heart Foundation of Australia. This studywas partially supported by a Partnership grant from the National Health and Medical Research Council (1149692), Canberra, Australia, Diabetes Australia, the Tasmanian Community Fund and Siemens Healthcare Australia. ECG equipment and software support were provided by Semacare Inc., a manufacturer of handheld ECG devices. The sponsors had no role in the design and conduct of the study, in the collection, analysis, and interpretation of the data, and in the preparation, review, or approval of the manuscript.