Elucidating the molecular and developmental biology of parasitic nematodes: Moving to a multiomics paradigm
Guangxu Ma, Tao Wang, Pasi K Korhonen, Andreas Hofmann, Paul W Sternberg, Neil D Young, Robin B Gasser
ADVANCES IN PARASITOLOGY, VOL 108 | Advances in Parasitology | ACADEMIC PRESS LTD-ELSEVIER SCIENCE LTD | Published : 2020
In the past two decades, significant progress has been made in the sequencing, assembly, annotation and analyses of genomes and transcriptomes of parasitic worms of socioeconomic importance. This progress has somewhat improved our knowledge and understanding of these pathogens at the molecular level. However, compared with the free-living nematode Caenorhabditis elegans, the areas of functional genomics, transcriptomics, proteomics and metabolomics of parasitic nematodes are still in their infancy, and there are major gaps in our knowledge and understanding of the molecular biology of parasitic nematodes. The information on signalling molecules, molecular pathways and microRNAs (miRNAs) that..View full abstract
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Awarded by ARC
Funding from the National Health and Medical Research Council (NHMRC) of Australia, Australian Research Council (ARC), BGI International Pty Ltd., Yourgene Health, Melbourne Water and The University of Melbourne (BIP) is gratefully acknowledged. N.D.Y. holds an NHMRC Career Development Fellowship, and P.K.K. holds an NHMRC Early Career Research Fellowship. Project support was through ARC grants LP180101334 (N.D.Y. and P.K.K.) and LP180101085 (R.B.G.).