Journal article

Propofol versus midazolam with or without short-acting opioids for sedation in colonoscopy: a systematic review and meta-analysis of satety, satistaction, and efficiency outcomes

Fahima Dossa, Braeden Medeiros, Christine Keng, Sergio A Acuna, Nancy N Baxter

GASTROINTESTINAL ENDOSCOPY | MOSBY-ELSEVIER | Published : 2020

Abstract

BACKGROUND AND AIMS: Propofol is increasingly being used for sedation in colonoscopy; however, its benefits over midazolam (± short-acting opioids) are not well quantified. The objective of this study was to compare safety, satisfaction, and efficiency outcomes of propofol versus midazolam (± short-acting opioids) in patients undergoing colonoscopy. METHODS: We systematically searched Medline, Embase, and the Cochrane library (to July 30, 2018) for randomized controlled trials of colonoscopies performed with propofol versus midazolam (± short-acting opioids). We pooled odds ratios for cardiorespiratory outcomes using mixed-effects conditional logistic models. We pooled standardized mean diff..

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