Journal article

Associations of Retinal Vessel Caliber With Hearing Status in Childhood and Midlife A Cross-Generational Population-Based Study

Jing Wang, Mengjiao Liu, Valerie Sung, Kate Lycett, Anneke Grobler, David Burgner, Tien Yin Wong, Melissa Wake

JAMA Otolaryngology–Head & Neck Surgery | AMER MEDICAL ASSOC | Published : 2020


Importance: Microvascular phenotypes, which can be assessed using retinal imaging, may be informative about the life course pathogenesis of hearing loss. Objective: To investigate whether differences in retinal vessel caliber (specifically wider venules and narrower arterioles) are associated with hearing threshold and hearing loss in mid-childhood and midlife. Design, Setting, and Participants: A population-based cross-sectional study (Child Health CheckPoint) was nested within the Longitudinal Study of Australian Children. A total of 1281 children and 1255 attending parents were assessed using retinal microvasculature and air conduction audiometry data at a main assessment center in 7 larg..

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Awarded by Australian National Health and Medical Research Council

Awarded by Royal Children's Hospital Foundation

Awarded by National Heart Foundation of Australia

Awarded by Financial Markets Foundation for Children

Funding Acknowledgements

This study was supported by grants 1041352 and 1109355 from the Australian National Health and Medical Research Council, grant 2014-241 from the Royal Children's Hospital Foundation, the Murdoch Children's Research Institute, the University of Melbourne, grant 100660 from the National Heart Foundation of Australia, grants 2014-055 and 2016-310 from the Financial Markets Foundation for Children, and the Victorian Deaf Education Institute. Research at the Murdoch Children's Research Institute is supported by the Victorian government's Operational Infrastructure Support Program. DrWang was supported by the MCRI Lifecourse Postdoctoral Fellowship. Ms Liu was supported by the University of Melbourne Postgraduate Scholarship. The following authors were supported by the Australian National Health and Medical Research Council: Dr Sung (Early Career Fellowship grant 1125687), Dr Lycett (Early Career Fellowship grant 1091124), Dr Burgner (Senior Research Fellowship grant 1064629), and DrWake (Senior Research Fellowship grant 1046518, Principal Research Fellowship grant 1160906). Additionally, Dr Sung was supported by a Cottrell Research Fellowship from the Royal Australasian College of Physicians, Dr Burgner by an Honorary Future Leader Fellowship of the National Heart Foundation of Australia (grant 100369), and DrWake by Cure Kids New Zealand.